English | 简体中文 | 繁體中文 | 한국어 | 日本語
Saturday, 9 November 2019, 00:00 HKT/SGT
Share:
    

Source: Novaliq GmbH
Novaliq and Jiangsu Hengrui Medicine Announce a Collaboration for Investigational NOV03 and CyclASol in China

HEIDELBERG / JIANGSU, Nov 9, 2019 - (ACN Newswire) - Novaliq GmbH, a pharmaceutical company focusing on first- and best-in-class ocular therapeutics, and Jiangsu Hengrui Medicine Co, Ltd. (SSE: 600276), a fully integrated biopharmaceutical company based in China, announced the closing of an exclusive license agreement to develop, manufacture and commercialize the innovative, water-free drugs NOV03 and CyclASol(R) for the treatment of dry eye disease in the People's Republic of China (mainland China, Hong Kong, Macau and Taiwan).


Novaliq - Logo


For an enhanced graphic, please visit: https://orders.newsfilecorp.com/files/6655/49568_enh.jpg

Dry eye disease (DED) is a chronic and serious disease of the ocular surface that negatively impacts quality of life comparably to other severe diseases. Patients present symptoms such as a feeling of dryness, burning, foreign body sensation or pain and report impairment of social functioning. Visual function-related manifestations including fluctuating vision with blinking, blurred vision and difficulty with reading, despite normal visual acuity, are important and underestimated aspects of the disease.

Eighty-six percent of patients with dry eye show signs of Meibomian gland dysfunction (MGD). NOV03 (perfluorohexyloctane) is being developed as a treatment for patients with dry eye disease associated with Meibomian gland dysfunction and has a novel mode of action that has been confirmed in various studies. Several clinical trials have demonstrated that NOV03 stabilizes the tear film lipid layer and protects from excessive evaporation. In addition, it has been shown to penetrate into the meibomian glands and liquefy secretions there, improving the quality of the meibum and the tear film lipid layer. NOV03 is being developed in phase three for the treatment of dry eye disease associated with Meibomian gland dysfunction (MGD) in the USA.

CyclASol is an anti-inflammatory investigational drug for patients with moderate to severe DED with an inflammatory disease component. CyclASol contains cyclosporine A 0.1% in EyeSol(R) and holds the promise of unfolding cyclosporine A's full potential on the ocular surface, enabling clinicians to treat more patients successfully. CyclASol is in phase three development for the treatment of dry eye disease in the USA. Both investigational drugs have shown in recent late-stage clinical trials superior efficacy results, with early onset of action and excellent tolerability profile. They are perceived as breakthrough medicines for dry eye patients worldwide with an unprecedented benefit-risk profile.

"Dry eye disease is common in China, but treatment options are very limited in China. We are committed to serving this unmet need and feel excited about the partnership with Novaliq, a leading company in ophthalmology with the world's first water-free eye drop platform. We shall work closely together with Novaliq to allow patients in China to benefit from this platform," said Piaoyang Sun, Chairman of the Board of Hengrui Medicine.

"We are excited about this strategic collaboration with Jiangsu Hengrui Medicine. We believe that Jiangsu Hengrui Medicine, as a leading biopharmaceutical company in China, is the ideal partner for us to maximize the commercial potential of our innovative products NOV03 and CyclASol in the Chinese market," said Christian Roesky, PhD, CEO of Novaliq. "With great benefits in terms of efficacy and tolerability, NOV03 and CyclASol can make a huge difference to the life of dry eye patients. We look forward to working with the team of Jiangsu Hengrui Medicine to bring these breakthrough medicines, if approved, to physicians and patients in the second biggest healthcare market in the most timely, efficient and effective way possible."

Under the terms of the agreement, Novaliq is eligible to receive an upfront payment of up to $9 million and up to $156 million in milestone payments linked to pre-defined development, regulatory and commercialization objectives. In addition, Jiangsu Hengrui Medicine will be obligated to pay Novaliq tiered percentage royalties on net sales of NOV03 and CyclASol in China. Thus, Jiangsu Hengrui Medicine secures exclusive rights to develop, manufacture and commercialize both drugs in China. Jiangsu Hengrui Medicine will be responsible for all development, regulatory and commercialization activities and related expenses in the territory.

About Jiangsu Hengrui Medicine Co., Ltd.
Jiangsu Hengrui Medicine Co., Ltd. established in 1970, is a leading biopharmaceutical company based in China with annual net sales of about $2.5 billion in 2018. Hengrui is devoted to empowering healthier lives through research, with capabilities across oncology, immunology, anesthesiology, cardiovascular diseases, metabolic diseases, and pain management. Hengrui has more than 140 clinical trials ongoing worldwide and an in-house sales force covering more than 18,000 hospitals in China.

About Novaliq GmbH
Novaliq is a pharmaceutical company focusing on the development and commercialization of first- and best-in-class ocular therapeutics based on EyeSol(R), the worldwide first water-free eye drop technology. Novaliq offers an industry-leading portfolio addressing today's unmet medical needs of millions of patients with eye diseases. Novaliq is headquartered in Heidelberg, Germany and has an office in Cambridge, MA, USA. The long-term shareholder is dievini Hopp BioTech holding GmbH & Co. KG, an active investor in Life and Health Sciences companies. More on www.novaliq.com.

Important notice: NOV03 and CyclASol(R) are investigational new drugs. NOV03 and CyclASol(R) are in late-stage clinical evaluation in the U.S. with an open IND by the U.S. Food and Drug Administration.

Media contact for Novaliq:
Heidrun Kirsch, VP Marketing, Novaliq GmbH, media@novaliq.com

Media contact for Jiangsu Hengrui Medicine:
Xiaohan Liu, Secretary of the Board, Jiangsu Hengrui Medicine Co., Ltd., liuxiaohan@hrs.com.cn

Sources:
- Schiffman RM, Walt JG, Jacobsen G, et al. Utility assessment among patients with dry eye disease. Ophthalmology. 2003;110(7):412-9
- Nelson JD, Craig JP, Akpek EK, Azar DT, Belmonte C, Bron AJ, et al. TFOS DEWS II Introduction. Ocul Surf. 2017;15(3):269-275
- Koh S. Mechanisms of visual disturbance in dry eye. Cornea. 2016;35(11): S.83-8
- Lemp et al. 2012; Cornea 31: 472-8

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/49568

Topic: Press release summary
Sectors: Daily Finance, Daily News, BioTech, HealthCare, Local Business
http://www.acnnewswire.com
From the Asia Corporate News Network


Copyright © 2019 ACN Newswire. All rights reserved. A division of Asia Corporate News Network.

 

Latest Press Releases
Layla Dong, a Female Leader Rebuilding Traditional Finance with Blockchain  
Nov 19, 2019 17:00 HKT/SGT
Hitachi and Cambridge Renew 30 Year Research Partnership  
Nov 19, 2019 12:01 HKT/SGT
Showa Denko to License Vinyl Acetate Monomer Technology to Shenghong Refining Petrochemical, China  
Nov 19, 2019 11:30 HKT/SGT
MSC Appoints Soren Toft as CEO for Container Shipping & Logistics  
Nov 19, 2019 10:00 HKT/SGT
Fujitsu and RIKEN Claim 1st Place in the Green500 with Prototype of Fugaku Supercomputer  
Nov 19, 2019 08:06 HKT/SGT
HPX announces that JCHX will become a 19.9% shareholder in Cordoba Minerals  
Nov 18, 2019 21:00 HKT/SGT
Wintermar secures 7-year contracts for 2 Platform Supply Vessels  
Nov 18, 2019 20:00 HKT/SGT
Toyota Mobility Foundation Joins Public, Private and Academic Parties to Launch the Rama4 Project to Ease Traffic Congestion in Bangkok  
Nov 18, 2019 16:30 HKT/SGT
Mazda3 Named 2019 Women's World Car of the Year  
Nov 18, 2019 14:39 HKT/SGT
MITSUBISHI MOTORS Launched Restyled Mirage and Attrage Compact Models in Thailand  
Nov 18, 2019 11:24 HKT/SGT
More Press release >>
 Events:
More events >>
Copyright © 2019 ACN Newswire - Asia Corporate News Network
Home | About us | Services | Partners | Events | Login | Contact us | Privacy Policy | Terms of Use | RSS
US: +1 800 291 0906 | Beijing: +86 400 879 3881 | Hong Kong: +852 8192 4922 | Singapore: +65 6653 1210 | Tokyo: +81 3 6859 8575