English | 简体中文 | 繁體中文 | 한국어 | 日本語
Monday, 31 October 2016, 19:09 JST
Share:
    

Source: Eisai
Enrollment Commences in Phase III Clinical Study of Eisai's BACE Inhibitor E2609 in Early Alzheimer's Disease

TOKYO, Oct 31, 2016 - (JCN Newswire) - Eisai Co., Ltd. announced today that enrollment has commenced in MISSION AD, a Phase III clinical program of the beta secretase cleaving enzyme (BACE) inhibitor E2609 in patients with early Alzheimer's disease in the United States. E2609 was discovered by Eisai and is being jointly developed by Eisai and Biogen Inc. as a potential Alzheimer's disease modifying treatment. Regarding the global conduct of the studies, Eisai and Biogen are currently in consultation with the regulatory authorities in the EU and Japan.

The first study of the MISSION AD program entitled MISSION AD1 (Study 301) is a global, multicenter, placebo-controlled, double-blind, parallel-group Phase III clinical study aiming to assess the efficacy and safety of E2609 in 1,330 patients with biomarker confirmed early Alzheimer's disease. The treatment group will be administered a dosage of 50 mg of E2609 daily during the treatment period of 24 months, and the primary endpoint will utilize the Clinical Dementia Rating Sum of Boxes (CDR-SB).

Discovered in-house by Eisai, E2609 is an investigational next-generation oral candidate for the treatment of AD that is believed to inhibit BACE, a key enzyme in the production of amyloid beta (Abeta). By inhibiting BACE, E2609 may decrease the formation of toxic Abeta peptide aggregates and amyloid plaques in the brain, thereby potentially slowing disease progression.

Lynn Kramer, M.D., Chief Clinical Officer and Chief Medical Officer of the Eisai Neurology Business Group, commented, "We are committed to helping those with Alzheimer's through the continued development of clinical studies with our BACE inhibitor targeting the production of Abeta proteins. Through the initiation of MISSION AD1 and similar clinical trials, we hope to demonstrate the value of this compound for those who suffer from early Alzheimer's disease."

Contact:
Public Relations Department,
Eisai Co., Ltd.
+81-3-3817-5120



Topic: Press release summary
Source: Eisai

Sectors: BioTech
https://www.acnnewswire.com
From the Asia Corporate News Network


Copyright © 2024 ACN Newswire. All rights reserved. A division of Asia Corporate News Network.

 

Eisai Related News
Monday, 23 December 2024, 17:22 JST
Fujirebio and Eisai Enter into Memorandum of Understanding for Joint Research and Social Implementation of Blood-based Biomarkers in the Field of Neurodegenerative Diseases
Wednesday, 11 December 2024, 14:45 JST
Eisai's "URECE(R)" (Dotinurad) Approved in China for Gout Patients with Hyperuricemia
Thursday, 5 December 2024, 11:22 JST
"LEQEMBI" (Lecanemab) Approved for the Treatment of Early Alzheimer's Disease in Mexico
Thursday, 28 November 2024, 16:26 JST
LEQEMBI (Lecanemab) for the Treatment of Alzheimer's Disease Launched in South Korea
Tuesday, 26 November 2024, 15:50 JST
Eisai Signs Research Collaboration Agreement with The National Center of Neurology and Psychiatry to Initiate Apolipoprotein E Genetic Testing in the "AD-DMT Registry" in Japan
More news >>
Copyright © 2024 ACN Newswire - Asia Corporate News Network
Home | About us | Services | Partners | Events | Login | Contact us | Cookies Policy | Privacy Policy | Disclaimer | Terms of Use | RSS
US: +1 214 890 4418 | China: +86 181 2376 3721 | Hong Kong: +852 8192 4922 | Singapore: +65 6549 7068 | Tokyo: +81 3 6859 8575